Effect of D1 receptor stimulation in normal and MPTP monkeys
Identifieur interne : 004A66 ( Main/Exploration ); précédent : 004A65; suivant : 004A67Effect of D1 receptor stimulation in normal and MPTP monkeys
Auteurs : Paul J. Bédard [Canada] ; René Boucher [Canada]Source :
- Neuroscience Letters [ 0304-3940 ] ; 1989.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (pharmacology), Agonist, Animal, Animals, Antagonist, Benzazepines (pharmacology), D1 Dopamine receptor, Degenerative disease, Dopamine Agents (pharmacology), Dopamine Antagonists, Dyskinesia, Dyskinesia, Drug-Induced, Ergolines (pharmacology), Experimental disease, Female, Macaca fascicularis, Motor Activity (drug effects), Nervous system diseases, Parkinson Disease, Secondary (chemically induced), Parkinson Disease, Secondary (physiopathology), Parkinson disease, Pathophysiology, Quinpirole, Receptors, Dopamine (physiology), Receptors, Dopamine D1, Sulpiride (pharmacology), «D2» Dopamine receptor.
- MESH :
- chemical , pharmacology : 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Benzazepines, Dopamine Agents, Ergolines, Sulpiride.
- chemical , physiology : Receptors, Dopamine.
- chemical : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Dopamine Antagonists, Quinpirole, Receptors, Dopamine D1.
- chemically induced : Parkinson Disease, Secondary.
- drug effects : Motor Activity.
- physiopathology : Parkinson Disease, Secondary.
- Animals, Dyskinesia, Drug-Induced, Female, Macaca fascicularis.
Abstract
The effect of a selective agonist of the dopamine D1 receptor (SKF 38393) and of the D2 receptor (LY-171555) was tested acutely in normal and in monkeys with a parkinsonian syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D2 agonist induced a strong locomotor response and lingual dyskinesia in both normal and parkinsonian monkeys. The D1 agonist however had no locomotor effect by itself but induced tongue protrusions in normal monkeys only. It appeared to potentiate the dyskinetic effect of LY 171555 in MPTP monkeys but it antagonized the locomotor action of the D2 agonist in both normal and MPTP monkeys. The selective D1 and D2 antagonists SCH 23390 and sulpiride were also tested. Both compounds were able to suppress the dyskinetic action of the combined agonists in normal animals but only the D2 antagonist was effective in the same conditions in MPTP monkeys. These findings emphasize the importance of the D2 receptor in mediating the locomotor response as well as dyskinesia in monkeys.
Url:
DOI: 10.1016/0304-3940(89)90358-3
Affiliations:
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Le document en format XML
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Bédard</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Département d'anatomie et Laboratoire de Neurobiologie, Faculté de Médecine, Université Laval, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Boucher, Rene" sort="Boucher, Rene" uniqKey="Boucher R" first="René" last="Boucher">René Boucher</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Département d'anatomie et Laboratoire de Neurobiologie, Faculté de Médecine, Université Laval, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuroscience Letters</title><title level="j" type="abbrev">NSL</title><idno type="ISSN">0304-3940</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1989">1989</date><biblScope unit="volume">104</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="223">223</biblScope><biblScope unit="page" to="228">228</biblScope></imprint><idno type="ISSN">0304-3940</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0304-3940</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (pharmacology)</term><term>Agonist</term><term>Animal</term><term>Animals</term><term>Antagonist</term><term>Benzazepines (pharmacology)</term><term>D1 Dopamine receptor</term><term>Degenerative disease</term><term>Dopamine Agents (pharmacology)</term><term>Dopamine Antagonists</term><term>Dyskinesia</term><term>Dyskinesia, Drug-Induced</term><term>Ergolines (pharmacology)</term><term>Experimental disease</term><term>Female</term><term>Macaca fascicularis</term><term>Motor Activity (drug effects)</term><term>Nervous system diseases</term><term>Parkinson Disease, Secondary (chemically induced)</term><term>Parkinson Disease, Secondary (physiopathology)</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Quinpirole</term><term>Receptors, Dopamine (physiology)</term><term>Receptors, Dopamine D1</term><term>Sulpiride (pharmacology)</term><term>«D2» Dopamine receptor</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine</term><term>Benzazepines</term><term>Dopamine Agents</term><term>Ergolines</term><term>Sulpiride</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptors, Dopamine</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Dopamine Antagonists</term><term>Quinpirole</term><term>Receptors, Dopamine D1</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Motor Activity</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease, Secondary</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dyskinesia, Drug-Induced</term><term>Female</term><term>Macaca fascicularis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Agoniste</term><term>Animal</term><term>Antagoniste</term><term>Dyskinésie</term><term>Extrapyramidal syndrome</term><term>MPTP</term><term>Maladie dégénérative</term><term>Mouvement involontaire</term><term>Parkinson maladie</term><term>Pathologie expérimentale</term><term>Physiopathologie</term><term>Récepteur dopaminergique D1</term><term>Récepteur dopaminergique D2</term><term>Système nerveux pathologie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effect of a selective agonist of the dopamine D1 receptor (SKF 38393) and of the D2 receptor (LY-171555) was tested acutely in normal and in monkeys with a parkinsonian syndrome induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). The D2 agonist induced a strong locomotor response and lingual dyskinesia in both normal and parkinsonian monkeys. The D1 agonist however had no locomotor effect by itself but induced tongue protrusions in normal monkeys only. It appeared to potentiate the dyskinetic effect of LY 171555 in MPTP monkeys but it antagonized the locomotor action of the D2 agonist in both normal and MPTP monkeys. The selective D1 and D2 antagonists SCH 23390 and sulpiride were also tested. Both compounds were able to suppress the dyskinetic action of the combined agonists in normal animals but only the D2 antagonist was effective in the same conditions in MPTP monkeys. These findings emphasize the importance of the D2 receptor in mediating the locomotor response as well as dyskinesia in monkeys.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Bedard, Paul J" sort="Bedard, Paul J" uniqKey="Bedard P" first="Paul J." last="Bédard">Paul J. Bédard</name></noRegion><name sortKey="Boucher, Rene" sort="Boucher, Rene" uniqKey="Boucher R" first="René" last="Boucher">René Boucher</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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